2024

49P Highly potent novel armoured IL13Ra2 CAR T cell targeting glioblastoma.

M. Mangolini, S. Srivastava, E. Souster, Y. Yang, R. Karatill, L. Schultz, B. Ma, D. Pombal, A. Ramon, M. Greenig, P. Sormanni, S. Cordoba, S. Onuoha. 

(2024)

. 

Immuno-Oncology and Technology. 

24. 
AIntibody: an experimentally validated in silico antibody discovery design challenge.

M. Frank Erasmus, Laura Spector, Fortunato Ferrara, Roberto DiNiro, Thomas J. Pohl, Katheryn Perea-Schmittle, Wei Wang, Peter M. Tessier, Crystal Richardson, Laure Turner et al. 

(2024)

. 

Nat Biotechnol. 

42. 
Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt.

Aubin Ramon, Mingyang Ni, Olga Predeina, Rebecca Gaffey, Patrick Kunz, Shimobi Onuoha, Pietro Sormanni. 

(2024)

. 

bioRxiv Preprint. 

Automated optimization of the solubility of a hyper-stable α-amylase.

Montader Ali, Matthew Greenig, Marc Oeller, Misha Atkinson, Xing Xu, Pietro Sormanni. 

(2024)

. 

Open Biol. 

14. 
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.

Robert I. Horne, Ewa A. Andrzejewska, Parvez Alam, Z. Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C. Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P. J. Knowles, Michele Vendruscolo. 

(2024)

. 

Nat Chem Biol. 

20. 
Targeted protein editing with an antibody-based system.

Michele Vendruscolo, Oded Rimon, Juraj Konc, Montader Ali, Vaidehi Roy Chowdhury, Pietro Sormanni, Gonçalo Bernardes. 

(2024)

. 

posted-content. 

Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV.

Aubin Ramon, Montader Ali, Misha Atkinson, Alessio Saturnino, Kieran Didi, Cristina Visentin, Stefano Ricagno, Xing Xu, Matthew Greenig, Pietro Sormanni. 

(2024)

. 

Nat Mach Intell. 

6. 

2023

Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.

Marc Oeller, Ryan J. D. Kang, Hannah L. Bolt, Ana L. Gomes dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo. 

(2023)

. 

Nat Commun. 

14. 
Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics.

Kuin Tian Pang, Yuan Sheng Yang, Wei Zhang, Ying Swan Ho, Pietro Sormanni, Thomas C.T. Michaels, Ian Walsh, Sean Chia. 

(2023)

. 

Biotechnology Advances. 

67. 
CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins.

Alessio Del Conte, Adel Bouhraoua, Mahta Mehdiabadi, Damiano Clementel, Alexander Miguel Monzon, , Alex S Holehouse, Daniel Griffith, Ryan J Emenecker, Ashwini Patil et al. 

(2023)

. 

51. 
AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering.

Aubin Ramon, Montader Ali, Misha Atkinson, Alessio Saturnino, Kieran Didi, Cristina Visentin, Stefano Ricagno, Xing Xu, Matthew Greenig, Pietro Sormanni. 

(2023)

. 

bioRxiv Preprint. 

Automated optimisation of solubility and conformational stability of antibodies and proteins.

Angelo Rosace, Anja Bennett, Marc Oeller, Mie M. Mortensen, Laila Sakhnini, Nikolai Lorenzen, Christian Poulsen, Pietro Sormanni. 

(2023)

. 

Nat Commun. 

14. 
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform.

Nadia A. Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwoger, Aviad Levin, Timothy J. Welsh, Runzhang Qi, Daoyuan Qian, Nikolai Lorenzen, Hongjia Zhu, Pietro Sormanni, Michele Vendruscolo, Tuomas P.J. Knowles. 

(2023)

. 

Anal. Chem. 

95. 
Sequence-based prediction of pH-dependent protein solubility using CamSol.

Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Michele Vendruscolo. 

(2023)

. 

24. 
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties.

Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier, Pietro Sormanni. 

(2023)

. 

mAbs. 

15. 

2022

Fragment-based computational design of antibodies targeting structured epitopes.

Mauricio Aguilar Rangel, Alice Bedwell, Elisa Costanzi, Ross J. Taylor, Rosaria Russo, Gonçalo J. L. Bernardes, Stefano Ricagno, Judith Frydman, Michele Vendruscolo, Pietro Sormanni. 

(2022)

. 

Sci. Adv. 

8. 
Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform.

Nadia A. Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwӧger, Aviad Levin, Timothy Welsh, Runzhang Qi, Daoyuan Qian, Hongjia Zhu, Pietro Sormanni, Michele Vendruscolo, Tuomas P.J. Knowles. 

(2022)

. 

bioRxiv Preprint. 

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.

Halina Mikolajek, Miriam Weckener, Z. Faidon Brotzakis, Jiandong Huo, Evmorfia V. Dalietou, Audrey Le Bas, Pietro Sormanni, Peter J. Harrison, Philip N. Ward, Steven Truong, Lucile Moynie, Daniel K. Clare, Maud Dumoux, Joshua Dormon, Chelsea Norman, Naveed Hussain, Vinod Vogirala, Raymond J. Owens, Michele Vendruscolo, James H. Naismith. 

(2022)

. 

Proc. Natl. Acad. Sci. U.S.A. 

119. 
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation.

Ross J. Taylor, Mauricio Aguilar Rangel, Michael B. Geeson, Pietro Sormanni, Michele Vendruscolo, Gonçalo J. L. Bernardes. 

(2022)

. 

J. Am. Chem. Soc. 

144. 
Editorial: Intrinsically Disordered Proteins and Regions: The Challenge to the Structure-Function Relationship.

Angelo Toto, Pietro Sormanni, Cristina Paissoni, Vladimir N. Uversky. 

(2022)

. 

Front. Mol. Biosci. 

9. 
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies.

Thomas Löhr, Pietro Sormanni, Michele Vendruscolo. 

(2022)

. 

Biomolecules. 

12. 
An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins.

Sara Linse, Pietro Sormanni, David J. O’Connell. 

(2022)

. 

Proc. Natl. Acad. Sci. U.S.A. 

119. 
Sequence-based pH-dependent prediction of protein solubility using CamSol.

Marc Oeller, Ryan Kang, Pietro Sormanni, Michele Vendruscolo. 

(2022)

. 

bioRxiv Preprint. 

Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics.

Rahul Khetan, Robin Curtis, Charlotte M. Deane, Johannes Thorling Hadsund, Uddipan Kar, Konrad Krawczyk, Daisuke Kuroda, Sarah A. Robinson, Pietro Sormanni, Kouhei Tsumoto, Jim Warwicker, Andrew C.R. Martin. 

(2022)

. 

mAbs. 

14. 
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.

Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P. Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H. Williams-Gray, Francesco A. Aprile, Pietro Sormanni, David Klenerman, Michele Vendruscolo. 

(2022)

. 

Chem. Sci. 

13. 

2021

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation.

Jennifer West, Sandeep Satapathy, Daniel R. Whiten, Megan Kelly, Nicholas J. Geraghty, Emma-Jayne Proctor, Pietro Sormanni, Michele Vendruscolo, Joel N. Buxbaum, Marie Ranson, Mark R. Wilson. 

(2021)

. 

Sci. Adv. 

7. 
An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement.

Marc Oeller, Pietro Sormanni, Michele Vendruscolo. 

(2021)

. 

Sci Rep. 

11. 
Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods.

Adriana-Michelle Wolf Pérez, Nikolai Lorenzen, Michele Vendruscolo, Pietro Sormanni. 

(2021)

. 

book-chapter. 

Critical assessment of protein intrinsic disorder prediction.

Marco Necci, Damiano Piovesan, , Md Tamjidul Hoque, Ian Walsh, Sumaiya Iqbal, Michele Vendruscolo, Pietro Sormanni, Chen Wang, Daniele Raimondi et al. 

(2021)

. 

Nat Methods. 

18. 
Crystal structure of the designed antibody DesAb-anti-HSA-P1.

E. Costanzi, P. Sormanni, S. Ricagno. 

(2021)

. 

component. 

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.

Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco et al. 

(2021)

. 

Front. Cell Dev. Biol. 

9. 
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures.

Tatsuya Ikenoue, Francesco A. Aprile, Pietro Sormanni, Michele Vendruscolo. 

(2021)

. 

Front. Neurosci. 

15. 
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases.

Klara Kulenkampff, Adriana-M. Wolf Perez, Pietro Sormanni, Johnny Habchi, Michele Vendruscolo. 

(2021)

. 

Nat Rev Chem. 

5. 
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.

Philip R. Lindstedt, Francesco A. Aprile, Pietro Sormanni, Robertinah Rakoto, Christopher M. Dobson, Gonçalo J.L. Bernardes, Michele Vendruscolo. 

(2021)

. 

Cell Chemical Biology. 

28. 
Computational maturation of a single-domain antibody against Aβ42 aggregation.

Jiacheng Lin, Chiara Figazzolo, Michael A. Metrick, Pietro Sormanni, Michele Vendruscolo. 

(2021)

. 

Chem. Sci. 

12. 

2020

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates.

Nabeel Ahmed, Ulrike A. Friedrich, Pietro Sormanni, Prajwal Ciryam, Naomi S. Altman, Bernd Bukau, Günter Kramer, Edward P. O'Brien. 

(2020)

. 

Journal of Molecular Biology. 

432. 
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease.

Tatsuya Ikenoue, Francesco A. Aprile, Pietro Sormanni, Francesco S. Ruggeri, Michele Perni, Gabriella T. Heller, Christian P. Haas, Christoph Middel, Ryan Limbocker, Benedetta Mannini, Thomas C. T. Michaels, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo. 

(2020)

. 

Sci Rep. 

10. 
Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers.

Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K. Wright, Ryan P. Kreiser, J. Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R. Kumita, Francesco S. Ruggeri, Christopher M. Dobson, Fabrizio Chiti, Francesco A. Aprile, Michele Vendruscolo. 

(2020)

. 

IJMS. 

21. 
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.

Francesco A. Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur, Lisa-Maria Needham, Francesco S. Ruggeri, Michele Perni, Ryan Limbocker, Gabriella T. Heller, Tomas Sneideris, Tom Scheidt, Benedetta Mannini, Johnny Habchi, Steven F. Lee, Patricia C. Salinas, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo. 

(2020)

. 

Proc. Natl. Acad. Sci. U.S.A. 

117. 
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.

Martina Maritan, Margherita Romeo, Luca Oberti, Pietro Sormanni, Masayoshi Tasaki, Rosaria Russo, Arianna Ambrosetti, Paolo Motta, Paola Rognoni, Giulia Mazzini, Alberto Barbiroli, Giovanni Palladini, Michele Vendruscolo, Luisa Diomede, Martino Bolognesi, Giampaolo Merlini, Francesca Lavatelli, Stefano Ricagno. 

(2020)

. 

Journal of Molecular Biology. 

432. 

2019

Proteome-wide observation of the phenomenon of life on the edge of solubility.

Giulia Vecchi, Pietro Sormanni, Benedetta Mannini, Andrea Vandelli, Gian Gaetano Tartaglia, Christopher M. Dobson, F. Ulrich Hartl, Michele Vendruscolo. 

(2019)

. 

Proc. Natl. Acad. Sci. U.S.A. 

117. 
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.

Rosie Freer, Pietro Sormanni, Prajwal Ciryam, Burkhard Rammner, Silvio O. Rizzoli, Christopher M. Dobson, Michele Vendruscolo. 

(2019)

. 

Heliyon. 

5. 
Biochemical and biophysical comparison of human and mouse beta‐2 microglobulin reveals the molecular determinants of low amyloid propensity.

Adnane Achour, Luca Broggini, Xiao Han, Renhua Sun, Carlo Santambrogio, Jeremie Buratto, Cristina Visentin, Alberto Barbiroli, Chiara Maria Giulia De Luca, Pietro Sormanni, Fabio Moda, Alfonso De Simone, Tatyana Sandalova, Rita Grandori, Carlo Camilloni, Stefano Ricagno. 

(2019)

. 

The FEBS Journal. 

287. 
Attentive Cross-Modal Paratope Prediction.

Andreea Deac, Petar VeliČković, Pietro Sormanni. 

(2019)

. 

Journal of Computational Biology. 

26. 
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.

Ajeet K. Sharma, Pietro Sormanni, Nabeel Ahmed, Prajwal Ciryam, Ulrike A. Friedrich, Günter Kramer, Edward P. O’Brien. 

(2019)

. 

PLoS Comput Biol. 

15. 
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming.

Nabeel Ahmed, Pietro Sormanni, Prajwal Ciryam, Michele Vendruscolo, Christopher M. Dobson, Edward P. O’Brien. 

(2019)

. 

Sci Rep. 

9. 
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman. 

(2019)

. 

Nat Commun. 

10. 
Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations.

Martina Maritan, Arianna Ambrosetti, Luca Oberti, Alberto Barbiroli, Luisa Diomede, Margherita Romeo, Francesca Lavatelli, Pietro Sormanni, Giovanni Palladini, Martino Bolognesi, Giampaolo Merlini, Stefano Ricagno. 

(2019)

. 

Amyloid. 

26. 
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.

Kalyani Sanagavarapu, Elisabeth Nüske, Irem Nasir, Georg Meisl, Jasper N. Immink, Pietro Sormanni, Michele Vendruscolo, Tuomas P. J. Knowles, Anders Malmendal, Celia Cabaleiro-Lago, Sara Linse. 

(2019)

. 

Sci Rep. 

9. 
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis.

Pietro Sormanni, Michele Vendruscolo. 

(2019)

. 

Cold Spring Harb Perspect Biol. 

11. 
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.

Adriana-Michelle Wolf Pérez, Pietro Sormanni, Jonathan Sonne Andersen, Laila Ismail Sakhnini, Ileana Rodriguez-Leon, Jais Rose Bjelke, Annette Juhl Gajhede, Leonardo De Maria, Daniel E. Otzen, Michele Vendruscolo, Nikolai Lorenzen. 

(2019)

. 

mAbs. 

11. 

2018

Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.

Lu Shan, Neil Mody, Pietro Sormanni, Kim L. Rosenthal, Melissa M. Damschroder, Reza Esfandiary. 

(2018)

. 

Mol. Pharmaceutics. 

15. 
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Michele Perni, Pavan K. Challa, Julius B. Kirkegaard, Ryan Limbocker, Mandy Koopman, Maarten C. Hardenberg, Pietro Sormanni, Thomas Müller, Kadi L. Saar, Lianne W.Y. Roode, Johnny Habchi, Giulia Vecchi, Nilumi Fernando, Samuel Casford, Ellen A.A. Nollen, Michele Vendruscolo, Christopher M. Dobson, Tuomas P.J. Knowles. 

(2018)

. 

Journal of Neuroscience Methods. 

306. 
O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES.

Francesco Antonio Aprile, Pietro Sormanni, Michele Perni, Paolo Arosio, Ryan Limbocker, Shianne Chhangur, Benedetta Mannini, Sara Linse, Tuomas Knowles, Christopher M. Dobson, Michele Vendruscolo. 

(2018)

. 

Alzheimer's & Dementia. 

14. 
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

Marie Nicole Bongiovanni, Francesco Antonio Aprile, Pietro Sormanni, Michele Vendruscolo. 

(2018)

. 

IJMS. 

19. 
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Tanguy Le Marchand, Matteo de Rosa, Nicola Salvi, Benedetta Maria Sala, Loren B. Andreas, Emeline Barbet-Massin, Pietro Sormanni, Alberto Barbiroli, Riccardo Porcari, Cristiano Sousa Mota, Daniele de Sanctis, Martino Bolognesi, Lyndon Emsley, Vittorio Bellotti, Martin Blackledge, Carlo Camilloni, Guido Pintacuda, Stefano Ricagno. 

(2018)

. 

Nat Commun. 

9. 
Parapred: antibody paratope prediction using convolutional and recurrent neural networks.

Edgar Liberis, Petar Veličković, Pietro Sormanni, Michele Vendruscolo, Pietro Liò. 

(2018)

. 

34. 
Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.

Marcel Stenvang, Nicholas P. Schafer, Kirsten Gade Malmos, Adriana-Michelle Wolf Pérez, Olatz Niembro, Pietro Sormanni, Rajiv Vaid Basaiawmoit, Gunna Christiansen, Maria Andreasen, Daniel E. Otzen. 

(2018)

. 

Journal of Molecular Biology. 

430. 
Third generation antibody discovery methods:<i>in silico</i>rational design.

Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo. 

(2018)

. 

Chem. Soc. Rev. 

47. 

2017

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

Damiano Piovesan, Francesco Tabaro, Lisanna Paladin, Marco Necci, Ivan Mičetić, Carlo Camilloni, Norman Davey, Zsuzsanna Dosztányi, Bálint Mészáros, Alexander M Monzon, Gustavo Parisi, Eva Schad, Pietro Sormanni, Peter Tompa, Michele Vendruscolo, Wim F Vranken, Silvio C E Tosatto. 

(2017)

. 

46. 
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

Michele Perni, Francesco A. Aprile, Sam Casford, Benedetta Mannini, Pietro Sormanni, Christopher M. Dobson, Michele Vendruscolo. 

(2017)

. 

Sci Rep. 

7. 
Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.

Nuria Martínez‐Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes. 

(2017)

. 

Angewandte Chemie. 

129. 
Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.

Nuria Martínez‐Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes. 

(2017)

. 

Angew Chem Int Ed. 

56. 
Paratope Prediction using Convolutional and Recurrent Neural Networks.

Edgar Liberis, Petar Veličković, Pietro Sormanni, Michele Vendruscolo, Pietro Liò. 

(2017)

. 

bioRxiv Preprint. 

Rapid and accurate in silico solubility screening of a monoclonal antibody library.

Pietro Sormanni, Leanne Amery, Sofia Ekizoglou, Michele Vendruscolo, Bojana Popovic. 

(2017)

. 

Sci Rep. 

7. 
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Francesco A. Aprile, Pietro Sormanni, Michele Perni, Paolo Arosio, Sara Linse, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo. 

(2017)

. 

Sci. Adv. 

3. 
Simultaneous quantification of protein order and disorder.

Pietro Sormanni, Damiano Piovesan, Gabriella T Heller, Massimiliano Bonomi, Predrag Kukic, Carlo Camilloni, Monika Fuxreiter, Zsuzsanna Dosztanyi, Rohit V Pappu, M Madan Babu, Sonia Longhi, Peter Tompa, A Keith Dunker, Vladimir N Uversky, Silvio C E Tosatto, Michele Vendruscolo. 

(2017)

. 

Nat Chem Biol. 

13. 
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella et al. 

(2017)

. 

Proc. Natl. Acad. Sci. U.S.A. 

114. 

2016

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease.

Rosie Freer, Pietro Sormanni, Giulia Vecchi, Prajwal Ciryam, Christopher M. Dobson, Michele Vendruscolo. 

(2016)

. 

Sci. Adv. 

2. 
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.

Carlo Camilloni, Benedetta Maria Sala, Pietro Sormanni, Riccardo Porcari, Alessandra Corazza, Matteo De Rosa, Stefano Zanini, Alberto Barbiroli, Gennaro Esposito, Martino Bolognesi, Vittorio Bellotti, Michele Vendruscolo, Stefano Ricagno. 

(2016)

. 

Sci Rep. 

6. 

2015

Targeting disordered proteins with small molecules using entropy.

Gabriella T. Heller, Pietro Sormanni, Michele Vendruscolo. 

(2015)

. 

Trends in Biochemical Sciences. 

40. 
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.

Francesco A. Aprile, Pietro Sormanni, Michele Vendruscolo. 

(2015)

. 

Biochemistry. 

54. 
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.

Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo. 

(2015)

. 

Proc. Natl. Acad. Sci. U.S.A. 

112. 
The s2D Method: Simultaneous Sequence-Based Prediction of the Statistical Populations of Ordered and Disordered Regions in Proteins.

Pietro Sormanni, Carlo Camilloni, Piero Fariselli, Michele Vendruscolo. 

(2015)

. 

Journal of Molecular Biology. 

427. 
The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility.

Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo. 

(2015)

. 

Journal of Molecular Biology. 

427. 
MonteGrappa: An iterative Monte Carlo program to optimize biomolecular potentials in simplified models.

G. Tiana, F. Villa, Y. Zhan, R. Capelli, C. Paissoni, P. Sormanni, E. Heard, L. Giorgetti, R. Meloni. 

(2015)

. 

Computer Physics Communications. 

186. 

2014

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Stefano Gianni, Carlo Camilloni, Rajanish Giri, Angelo Toto, Daniela Bonetti, Angela Morrone, Pietro Sormanni, Maurizio Brunori, Michele Vendruscolo. 

(2014)

. 

Proc. Natl. Acad. Sci. U.S.A. 

111. 
Iterative derivation of effective potentials to sample the conformational space of proteins at atomistic scale.

Riccardo Capelli, Cristina Paissoni, Pietro Sormanni, Guido Tiana. 

(2014)

. 

140. 

2013

Subdomain Architecture and Stability of a Giant Repeat Protein.

Maksym Tsytlonok, Pietro Sormanni, Pamela J. E. Rowling, Michele Vendruscolo, Laura S. Itzhaki. 

(2013)

. 

J. Phys. Chem. B. 

117. 

2012

Fibrillogenic propensity of the GroEL apical domain: A Janus‐faced minichaperone.

Jin Chen, Hisashi Yagi, Pietro Sormanni, Michele Vendruscolo, Koki Makabe, Takashi Nakamura, Yuji Goto, Kunihiro Kuwajima. 

(2012)

. 

FEBS Letters. 

586.